Health

Background

Better safe than sorry

There is no silver bullet to tackle mycotoxin threats. To reduce the risk to bird and business health, a targeted approach is needed consisting of different tools evaluating the mycotoxin risk and safeguarding the feed and the animal from mycotoxins.

In total, more than 700 different mycotoxins have been identified, and some of them, like Aflatoxin (AFLA), Deoxynivalenol (DON), Zearalenone (ZEA), Fumonisin (FUM), T-2 and Ochratoxin (OTA) are major causes of economic losses to the agricultural industry.

Weather conditions during growing season

Weather conditions during the growing season are the most influential parameters for mycotoxin production, causing high year-to-year variation. Some years, mycotoxin contamination levels exceed the EU guidance levels, while many years report low level contamination. Adding more complexity is the fact that mycotoxin co-contamination is the rule rather than the exception; and while individual mycotoxins present a threat, synergistic effects of multiple occurring mycotoxins and their interaction with diseases are more critical to health.

While poor animal performance is of economic importance, the effect of many mycotoxins on the immune system of the animals is of increased concern. - Photo: Smit Saengchot
While poor animal performance is of economic importance, the effect of many mycotoxins on the immune system of the animals is of increased concern. - Photo: Smit Saengchot

A defined strategy is needed

Mycotoxins give rise to many different pathological effects in animals, leading to decreased performance and welfare. While poor animal performance is of economic importance, the effect of many mycotoxins on the immune system of the animals is of increased concern. Research shows several mycotoxins could impact vaccination efficiency, and/or increase the susceptibility of animals to viral, bacterial and parasitic diseases. This is not to forget the well-known negative impact of mycotoxins on the intestinal morphology and function compromising gut health. It is clear that mycotoxins:

 

  • are produced by moulds growing on feeds and their raw materials
  • occur seasonally and pose difficulties in evaluating the mycotoxin risk
  • negatively impact animal health and performance.

 

Consequently, there is no single solution for coping with mycotoxins: a defined strategy is needed.

A mycotoxin management toolbox

As the silver bullet for mycotoxin management is non-existent, a complete strategy focusing on the preservation of feed and raw materials, as well as monitoring their contamination and protecting the animal deserves attention.

TOOL#1 – Tackle the cause of the problem with a preservative

The first step in managing mycotoxins is to prevent mycotoxin production by moulds in feed and raw materials. While crops are growing, mould presence is hard to control and highly dependent on variable factors like the weather. During storage, it is easy and practical to use an effective mould inhibitor to preserve feed and raw materials.

TOOL#2 – Evaluate the risk with routine mycotoxin screening

As mycotoxins are emerging as major contaminants of feeds and raw materials, it is important to evaluate their prevalence. Proper sampling procedures of feed and raw materials need to be established to allow a correct estimation of the mycotoxin risk.

Several methods are available for mycotoxin detection, all with their own advantages and limitations. For example, ELISA can be used as a rapid in-field detection method, while LC-MS/MS is a more specific and sensitive method for the detection of mycotoxins but requires specific lab skills.

To partner with our customers and to help maintain feed quality and safety, Kemin performs routine mycotoxin analysis on feed and raw material samples. After a thorough screening of those samples, resulting in a clear view on the mycotoxin risk, a tailor-made mycotoxin prevention program is offered. Secondly, all results are gathered in a biyearly mycotoxin survey, allowing the correct implementation of control programs. For Europe, 314 samples were analysed during the first half of 2019. More samples tested positive for Ht-2/T-2 and less samples tested positive for DON compared to the same period last year. Most samples were contaminated with two or more different mycotoxins.

Better safe than sorry

TOOL#3 – Protect the animal with a mycotoxin binder

Clearly, the presence of mycotoxins in feeds poses a heavy burden on the health of the animal. Consequently, the protection of the animal is a must, preferably by a preventive strategy. The strategy to safeguard your animals is the use of a mycotoxin binder, consisting of adsorbents that bind the relevant mycotoxins along the gastrointestinal tract, thereby reducing mycotoxin bioavailability and promoting their excretion from the animal’s body. Activation of different adsorbing ingredients ensures broad-spectrum binding efficacy over a wide pH range. Since no single adsorbent is effective against all relevant mycotoxins, a combination of activated binding agents can meet the essential requirements for a broad-spectrum mycotoxin binder.

Supported by research combining in vitro and in vivo studies, the Toxfin product range has shown to be effective under field conditions keeping animals healthy and efficacious in cases of mycotoxin exposure. For example, a trial was performed in broilers to evaluate the negative effects of an aflatoxin and ochratoxin contaminated diet on performance, organ and immune status. 192 ROSS 308 one-day old broilers were divided over four treatments for 35 days. At the age of 7 days, all birds were offered feed containing 57 ppb aflatoxin B1 (AFB1) and 23 ppb ochratoxin A (OTA), except the negative control group. All birds were vaccinated against Newcastle disease (NCD) at the first and 21st day of the trial. At day 35, birds were weighed, and blood samples were taken for ALT, a marker for liver damage, and NCD IgG titres measurement. Additionally, birds were necropsied to determine the weight of the Bursa of Fabricius and thymus.

The contaminated diet significantly reduced performance results (body weight) and compromised immune status (IgG titres, bursa and thymus weight) (Figure 1). Additionally, the mycotoxin contamination was responsible for severe liver damage, as serum ALT was significantly increased in the contaminated diet group compared to the negative control. A mycotoxin binder at 1kg and 2kg per tonne of feed was able to counteract those negative effects of the mycotoxin contaminated diet, as the values of final body weight, antibody titres, serum ALT and organ weight was brought back to the level of the non-contaminated diet. Findings of this trial show that Toxfin counteracts the negative effects on performance, immune and organ status of broilers fed a mycotoxin contaminated diet.

Author: Valentine Van Hamme, Kemin

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